Human MCSFR(Macrophage Colony Stimulating Factor Receptor) ELISA Kit

Size

£120.60

Was £134.00

SKU:: E-EL-H1525
Additional Names:: CSF1R,Colony stimulating factor 1 receptor,CD115,C-FMS,CSF-1R,FIM2,FMS,M-CSFR
Application:: ELISA
Physical State:: Other Biological Fluid, Plasma, Serum
Species Reactivity:: Human
Storage Conditions:: 2-8[o]C
Supplier:: Elabscience
Reactivities:: Human
Format:: Colorimetric method,ELISA,Sandwich
Uniprot:: P07333
Synonyms:: BANDDOS;C-FMS;CD115;CD115 antigen;CSF-1 receptor;CSF-1R;CSFR;FIM2;FMS;FMS proto-oncogene;HDLS;M-CSF-R;macrophage colony stimulating factor I receptor;macrophage colony-stimulating factor 1 receptor;McDonough feline sarcoma viral (v-fms) oncogene homolog;proto-oncogene c-Fms
Extra Details:: M-CSF Receptor (M-CSF R), the product of the c-fms proto-oncogene, is a member of the type III subfamily of receptor tyrosine kinases that also includes receptors for SCF and PDGF. These receptors each contain five immunoglobulin-like domains in their extracellular domain (ECD) and a split kinase domain in their intracellular region. M-CSF Receptor is expressed primarily on cells of the monocyte/macrophage lineage, dendritic cells, stem cells and in the developing placenta. Human M-CSF Receptor cDNA encodes a 972 amino acid (aa) type I membrane protein with a 19 aa signal peptide, a 493 aa extracellular region containing the ligand-binding domain, a 25 aa transmembrane domain, and a 435 aa cytoplasmic domain. The human M-CSF R ECD shares 60%, 64%, 72%, 75%, 75%, and 76% aa identity with mouse, rat, bovine, canine, feline, and equine M-CSF R, respectively. Activators of protein kinase C induce TACE/ADAM17 cleavage of the M-CSF Receptor, releasing the functional ligand-binding extracellular domain. M-CSF binding induces receptor homodimerization, resulting in transphosphorylation of specific cytoplasmic tyrosine residues and signal transduction. The intracellular domain of activated M-CSF R binds more than 150 proteins that affect cell proliferation, survival, differentiation and cytoskeletal reorganization. Among these, PI3Kinase, P42/44 ERK, and c-Cbl are key transducers of M-CSF R signals. M-CSF R engagement is continuously required for macrophage survival and regulates lineage decisions and maturation of monocytes, macrophages, osteoclasts and DC. M-CSF R and Integrin alpha v beta 3 share signaling pathways during osteoclastogenesis and deletion of either causes osteopetrosis . In the brain, microglia expressing increased M-CSF R are concentrated with Alzheimers a beta peptide, but their role in pathogenesis is unclear.

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