Human Cyr61(Cysteine Rich Protein, Angiogenic Inducer 61) ELISA Kit

Size

£128.70

Was £143.00

SKU:: E-EL-H1285
Additional Names:: CCN1,GIG1,IGFBP10
Application:: ELISA
Physical State:: Other Biological Fluid, Plasma, Serum
Species Reactivity:: Human
Storage Conditions:: 2-8[o]C
Supplier:: Elabscience
Format:: Colorimetric method,ELISA,Sandwich
Uniprot:: O00622
Synonyms:: CCN family member 1;CYR61;cysteine rich angiogenic inducer 61;Cysteine-rich angiogenic inducer 61;cysteine-rich heparin-binding protein 61;cysteine-rich, anigogenic inducer, 61;GIG1;IBP-10;IGF-binding protein 10;IGFBP-10;IGFBP10;insulin-like growth factor-binding protein 10;protein CYR61;Protein GIG1
Extra Details:: Cyr61 can promote cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CCN1-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3.