Human MCP-4/CCL13(Monocyte Chemotactic Protein 4) ELISA Kit

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£128.70

Was £143.00

SKU:: E-EL-H1159
Additional Names:: SCYA13,MCP-4,NCC-1,SCYL1,CKb10,CCL13
Application:: ELISA
Physical State:: Other Biological Fluid, Plasma, Serum
Species Reactivity:: Human
Storage Conditions:: 2-8[o]C
Supplier:: Elabscience
Format:: Colorimetric method,ELISA,Sandwich
Uniprot:: Q99616
Synonyms:: C-C motif chemokine 13;chemokine (C-C motif) ligand 13;CK-beta-10;CKb10;MCP-4;monocyte chemoattractant protein 4;monocyte chemotactic protein 4;NCC-1;NCC1;new CC chemokine 1;SCYA13;SCYL1;small inducible cytokine subfamily A (Cys-Cys), member 13;small-inducible cytokine A13
Extra Details:: CCL13 (MCP-4) was initially identified in a library constructed from human fetal mRNA.CCL13 is constitutively expressed at high levels in the small intestine, colon, and lung. Original data showed that CCL13 was less effective than MCP-1 and MCP-3 in monocyte and lymphocyte chemoattraction, but equivalent to eotaxin as a chemoattractant for eosinophils. Chemokines are very important in the inflammatory process, initially in the influx of PMN by CXC chemokines and subsequently chemoattracting monocytes where the MCPs participate, including CCL13. The bioactivity of pro-inflammatory chemokines is regulated by MMPs in order to regulate the influx of different cell subpopulations. CCL13 is involved in inflammatory diseases such as rheumatoid arthritis (RA), atherosclerosis, and asthma. High levels of CCL13 have been detected in the synovial fluid of patients with RA, in serum of asthmatic patients, and in plasma of patients with symptomatic carotid atherosclerosis.

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