PE Anti-Human CD23 Antibody[EBVCS2]

Size

£104.40

Was £116.00

SKU:: E-AB-F1382D
Additional Names:: B6,BLAST-2,FcE EpsilonRII,IgE Fc Receptor,Leu-20,Low affinity IgE receptor
Application:: Flow Cytometry
Storage Conditions:: 2-8[o]C Do not freeze. Protect from light.
Supplier:: Elabscience
Host:: Mouse
Reactivities:: Human
Buffer:: PBS
Immunogen:: CD23
Clone:: EBVCS2
Uniprot:: P06734
Synonyms:: BLAST-2;C-type lectin domain family 4 member J;C-type lectin domain family 4, member J;CD23;CD23 antigen;CD23A;CLEC4J;Fc epsilon receptor II;Fc fragment of IgE, low affinity II, receptor for (CD23);fc-epsilon-RII;FCE2;IGEBF;immunoglobulin E-binding factor;immunoglobulin epsilon-chain;low affinity immunoglobulin epsilon Fc receptor;lymphocyte IgE receptor
Extra Details:: CD23 is a 45 kD protein, also known as Leu-20, FcE EpsilonRII, IgE Fc receptor, BLAST-2, B6, and low affinity IgE receptor. It is a member of the Ig family, expressed on most mature B cells, B cells in follicular mantle (but not in proliferating germinal center cells, follicular dendritic cells, monocytes, eosinophils, Langerhans cells, and a subset of T cells (10-15% of tonsillar T cells). CD23 responds to high levels of IgE by downregulating IgE secretion. In human monocytes, CD23 triggering results in release of pro-inflammatory cytokines including TNF-A Alpha, IL-1, IL-6, and GM-CSF. CD23 can be proteolytically cleaved to generate soluble CD23 fragments of various molecular weights. In chronic lymphocytic leukemia, levels of soluble CD23 in the serum can be used as a prognostic marker to identify patients at high risk for disease progression. Alternate splicing of exon 2 can also generate two cell-surface isoforms of CD23 differing by 6 amino acids in their cytoplasmic region.

Shipping Conditions:: Blue Ice