APC Anti-Mouse/Rat Foxp3 Antibody[FJK-16s]

Size

£156.60

Was £174.00

SKU:: E-AB-F1351E
Additional Names:: IPEXJM2ScurfinZinc finger protein JM2,Forkhead box protein P3
Application:: Flow Cytometry
Storage Conditions:: 2-8[o]C Do not freeze. Protect from light.
Supplier:: Elabscience
Host:: Rat
Reactivities:: Mouse, Rat
Buffer:: PBS
Immunogen:: Foxp3
Clone:: FJK-16s
Uniprot:: Q99JB6
Synonyms:: forkhead box protein P3;JM2;scu;scurfin;scurfy;sf
Extra Details:: FOXP3 is a 47 kD transcription factor, also known as Forkhead box protein P3, Scurfin, JM2, or IPEX. It is proposed to be a master regulatory gene and more specific marker of T regulatory cells than most cell surface markers (such as CD4 and CD25). Transduced expression of FOXP3 in CD4+/CD25- cells has been shown to induce GITR, CD103, and CTLA4 and impart a T regulatory cell phenotype. FOXP3 is mutated in X-linked autoimmunity-allergic dysregulation syndrome (XLAAD or IPEX) in humans and in "scurfy" mice. Overexpression of FOXP3 has been shown to lead to a hypoactive immune state suggesting that this transcriptional factor is a central regulator of T cell activity.