Elab Fluor[R] 700 Anti-Human/Monkey CD163 Antibody[GHI/61]

Size

£128.70

Was £143.00

SKU:: E-AB-F1298M1
Additional Names:: ED2(rat)Hemoglobin/Haptoglobin Complex ReceptorM130RM3/1macrophage-associated antigenp155,GHI/61
Application:: Flow Cytometry
Storage Conditions:: 2-8[o]C Do not freeze. Protect from light.
Supplier:: Elabscience
Host:: Mouse
Reactivities:: Human
Buffer:: PBS
Immunogen:: CD163
Clone:: GHI/61
Uniprot:: Q86VB7
Synonyms:: hemoglobin scavenger receptor;M130;macrophage-associated antigen;MM130;SCARI1;scavenger receptor cysteine-rich type 1 protein M130
Extra Details:: CD163 is a member of the group B scavenger receptor cysteine-rich superfamily, also known as GHI/61, M130, RM3/1, p155, hemoglobin-haptoglobin complex receptor, or macrophage-associated antigen. It is a 134 kD (non-reduced)/155 kD (reduced) glycoprotein primarily expressed on macrophages, Kupffer cells, monocytes, a subset of dendritic cells, and a subset of hematopoietic stem/progenitor cells. CD163 binds to haptoglobin-hemoglobin complex and TWEAK, and plays a role in clearing hemoglobin and regulating cytokine production by macrophages. Membrane CD163 can be cleaved by metalloproteinases (MMP), resulting in a soluble form. Elevated serum level of sCD163 has been implicated in many kinds of inflammatory diseases.