FITC Anti-Mouse CD172a/SIRPA Alpha Antibody[P84]

Size

£90.90

Was £101.00

SKU:: E-AB-F1286C
Additional Names:: BIT,CD172 antigen-like family member A,P84,PTPNS1,SHPS-1,SIRPA Alpha
Application:: Flow Cytometry
Storage Conditions:: 2-8[o]C Do not freeze. Protect from light.
Supplier:: Elabscience
Host:: Rat
Reactivities:: Mouse
Buffer:: PBS
Immunogen:: CD172a
Clone:: P84
Uniprot:: Q64314
Synonyms:: AI835480;AU040960;Bi;Bit;brain Ig-like molecule with tyrosine-based activation motifs;brain immunological-like with tyrosine-based motifs;CD172;CD172 antigen-like family member A;CD172a;cluster designation 34;hematopoietic progenitor cell antigen CD34;Idd13.2;inhibitory receptor SHPS-1;mSIRP-alpha1;myD-1 antigen;P8;P84;protein tyrosine phosphatase, non-receptor type substrate 1;Pt;Ptpns1;SHP;SHP substrate 1;SHP-1;SHPS-1;signal-regulatory protein alpha-1;SIRP;sirp-alpha-1;tyrosine-protein phosphatase non-receptor type substrate 1
Extra Details:: CD172a, also known as SIRPA Alpha, is a type I transmembrane protein with one V-set Ig-like and two C-set Ig-like domains in the extracellular portion, and two ITIM motifs and a proline-rich region in the cytoplasmic tail. CD172a is expressed by monocytes, macrophages, myeloid cells, and neuronal tissue. The phosphorylation of SIRPA Alpha ITIMs induces the recruitment and activation of the tyrosine phosphatases PTPN6 and PTPN11, resulting in the negative regulation of several biological processes. The ligands of CD172a are CD47, SP-A, and SP-D.