PE Anti-Human CD8a Antibody[HIT8a]

Size

£59.40

Was £66.00

SKU:: E-AB-F1271D
Additional Names:: CD8Leu-2Ly-2,CD8,CD8 antigen alpha po,CD8 antigen alpha polypeptide,CD8A,Leu,Leu2,MAL,T-cell surface glycoprotein CD8 alpha chain,T-lymphocyte differentiation antigen T8/Leu,T-lymphocyte differentiation antigen T8/Leu-2,T8,alpha polypeptide (p32),p32
Application:: Flow Cytometry
Storage Conditions:: 2-8[o]C Do not freeze. Protect from light.
Supplier:: Elabscience
Host:: Mouse
Reactivities:: Human
Buffer:: PBS
Immunogen:: CD8a
Clone:: HIT8a
Uniprot:: P01732
Synonyms:: CD8;CD8 antigen, alpha polypeptide (p32);Leu2;Leu2 T-lymphocyte antigen;OKT8 T-cell antigen;p32;T cell co-receptor;T-cell antigen Leu2;T-cell surface glycoprotein CD8 alpha chain;T-lymphocyte differentiation antigen T8/Leu-2;T8 T-cell antigen
Extra Details:: CD8a is a 32-34 kD type I glycoprotein. It forms a homodimer (CD8a/a) or heterodimer (CD8a/b) with CD8b. CD8, also known as T8 and Leu2, is a member of the immunoglobulin superfamily found on the majority of thymocytes, a subset of peripheral blood T cells, and NK cells (which express almost exclusively CD8a homodimers). CD8 acts as a co-receptor with MHC class I-restricted T cell receptors in antigen recognition and T cell activation and has been shown to play a role in thymic differentiation. Two domains in CD8a are important for function: the extracellular IgSF domain binds the A Alpha3 domain of MHC class I and the cytoplasmic CXCP motif binds the tyrosine kinase p56 Lck.