APC Anti-Mouse Foxp3 Antibody[3G3]

Size

£166.50

Was £185.00

SKU:: E-AB-F1238E
Additional Names:: Forkhead box protein P3,Foxp3,IPEX,JM2
Application:: Flow Cytometry
Storage Conditions:: 2-8[o]C Do not freeze. Protect from light.
Supplier:: Elabscience
Host:: Mouse
Reactivities:: Mouse
Buffer:: PBS
Immunogen:: Foxp3
Clone:: 3G3
Uniprot:: Q99JB6
Synonyms:: forkhead box protein P3;JM2;scu;scurfin;scurfy;sf
Extra Details:: FOXP3 is a 50-55 kD transcription factor, also known as Forkhead box protein P3, Scurfin, JM2, or IPEX. It is proposed to be a master regulatory gene and more specific marker of T regulatory cells than most cell surface markers (such as CD4 and CD25). Transduced expression of FOXP3 in CD4+/CD25- cells has been shown to induce GITR, CD103, and CTLA4 and impart a T regulatory cell phenotype. FOXP3 is mutated in X-linked autoimmunity-allergic dysregulation syndrome (XLAAD or IPEX) in humans and in 'scurfy' mice. Overexpression of FOXP3 has been shown to lead to a hypoactive immune state suggesting that this transcriptional factor is a central regulator of T cell activity. In human, unlike in mouse, two isoforms of FOXP3 have been reported: one (FOXP3) corresponding to the canonical full-length sequence, the other (FOXP3 D Delta2) lacking exon 2.