APC Anti-Rat CD45 Antibody[OX-1]

Size

£78.30

Was £87.00

SKU:: E-AB-F1227E
Additional Names:: LCALy-5T200,Leukocyte common antigen,Ptprc,Receptor-type tyrosine-protein phosphatase C
Application:: Flow Cytometry
Storage Conditions:: 2-8[o]C Do not freeze. Protect from light.
Supplier:: Elabscience
Host:: Mouse
Reactivities:: Rat
Buffer:: PBS
Immunogen:: CD45
Clone:: OX-1
Uniprot:: P04157
Synonyms:: AI605264;CD-45-;CD-45-AP;CD45;CD45-AP;CD45-associated protein;L-CA;Lca;leucocyte common antigen;Leukocyte common antigen;leukocyte common antigen A;leukocyte common antigen B;LPAP;LSM;LSM-1;protein tyrosine phosphatase receptor type C-associated protein;protein tyrosine phosphatase, receptor-type, c polypeptide;PTPRC-associated protein;receptor-type tyrosine-protein phosphatase C;RT7;T200;T200 glycoprotein
Extra Details:: CD45 is a 180-220 kD protein also known as leukocyte common antigen (LCA). It is a protein tyrosine phosphatase with multiple isoforms differing as a result of alternative splicing of the extracellular domain and glycosylation. CD45 is expressed on all hematopoietic cells except erythrocytes and platelets, isoform expression depends on cell type, activation state, and cell maturation. CD45 functions in signal transduction through T and B cell antigen receptors. CD45 has been shown to interact with various proteins including galectin-1, CD2, CD3, and CD4. The OX-1 antibody has been shown to partially inhibit NK cell-mediated lysis of syngeneic tumor cells in vitro.