Purified Anti-Human CD28 Antibody[CD28.2], Functional Grade

Size

£80.10

Was £89.00

SKU:: E-AB-F11950
Additional Names:: GPSAT,GYPA,HGpMiX,MNS,PAS2
Application:: Flow Cytometry
Concentration:: >= 1 mg/ml
Storage Conditions:: 2-8[o]C Avoid freeze/thaw cycles., -20[o]C Avoid freeze/thaw cycles.
Supplier:: Elabscience
Host:: Mouse
Reactivities:: Human
Buffer:: Sterile PBS, pH 7.2. < 1.0 EU per mg of the antibody as determined by the LAL method.
Clone:: CD28.2
Uniprot:: P10747
Synonyms:: T-cell-specific surface glycoprotein CD28;Tp44
Extra Details:: CD28 is a 44 kD disulfide-linked homodimeric type I glycoprotein. It is a member of the immunoglobulin superfamily and is also known as T44 or Tp44. CD28 is expressed on most T lineage cells, NK cell subsets, and plasma cells. CD28 binds both CD80 and CD86 using a highly conserved motif MYPPY in the CDR3-like loop. CD28 is considered a major co-stimulatory molecule, inducing T lymphocyte activation and IL-2 synthesis, and preventing cell death. In vitro studies indicate that ligation of CD28 on T cells by CD80 and CD86 on antigen presenting cells provides a costimulatory signal required for T cell activation and proliferation. None (Azide-Free,Low Endotoxin) are perfectly suited to be used in culture or in vivo (for nonhuman studies) for functional assays blocking, neutralizing, activation or depletion where the presence of azide may damage cells or exogenous endotoxin may signal or activate cells.