APC Anti-Mouse FcE EpsilonRIA Alpha Antibody[MAR-1]

Size

£78.30

Was £87.00

SKU:: E-AB-F1188E
Additional Names:: Fc-epsilon RI-alpha,FcERI,Fcer1a,High affinity immunoglobulin epsilon receptor subunit alpha
Application:: Flow Cytometry
Storage Conditions:: 2-8[o]C Do not freeze. Protect from light.
Supplier:: Elabscience
Host:: Hamster
Reactivities:: Mouse
Buffer:: PBS
Immunogen:: FcεRIα
Clone:: MAR-1
Uniprot:: P20489
Synonyms:: fc-epsilon RI-alpha;FcE;Fce1;Fce1a;fcepsilonri;FcERI;Fcr-;Fcr-5;high affinity immunoglobulin epsilon receptor subunit alpha;igE Fc receptor subunit alpha
Extra Details:: FcE EpsilonRIA Alpha is a transmembrane protein belonging to the Ig superfamily. FcE EpsilonRIA Alpha forms a tetrameric complex with one B Beta and two G Gamma-subunits. The FcE EpsilonRI complex plays an important role in triggering IgE-mediated allergic reactions. It is abundantly expressed on mast and basophils and up-regulated by the presence of IgE. Following stimulation via FcE EpsilonRIA Alpha, mast cells and basophils release bioactive chemical mediators such as histamine, resulting in the initiation of allergic reactions. Cross linking of the high-affinity receptor for IgE on tissue mast cells triggers immediate hypersensitivity with local symptoms. The MAR-1 monoclonal antibody reacts with the FcE EpsilonRIA Alpha subunit.