E-AB-F11810
Purified Anti-Mouse CD326 Antibody[G8.8], Functional Grade
Size
£80.10
Was £89.00
- SKU:
- E-AB-F11810
- Additional Names:
- EGP,Megp,Tacstd,EGP314,Ep-CAM,Megp314,Tacstd1,Epcam, MK-1, KSA, EGP40,17 1A,323/A3,35-KD glycoprotein,Adenocarcinoma associated antigen,Adenocarcinoma-associated antigen,Antigen identified by monoclonal AUA1,AUA1,CD326,CD326 antigen,Cell surface glycoprotein Trop 1,Cell surface glycoprotein Trop 2,Cell surface glycoprotein Trop-1,chromosome 4,CO 17A,CO17 1A,CO17A,DIAR5,EGP 2,EGP2,EGP-2,EGP40,Ep CAM,EpCAM1,epithelial cell adhesion molecule,Epithelial Cell Adhesion Molecule Intracellular Domain
- Application:
- Flow Cytometry
- Concentration:
- >= 1 mg/ml
- Purification:
- protein a/g purified
- Storage Conditions:
- 2-8[o]C Avoid freeze/thaw cycles., -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rat
- Reactivities:
- Mouse
- Buffer:
- Sterile PBS, pH 7.2. < 1.0 EU per mg of the antibody as determined by the LAL method.
- Immunogen:
- Recombinant Mouse CD326 protein
- Clone:
- G8.8
- Uniprot:
- Q99JW5
- Synonyms:
- CD326;EGP;EGP-;EGP-2;Egp31;Egp314;Ep-C;Ep-CAM;EpC;EpCA;EpCAM1;epithelial cell adhesion molecule;epithelial glycoprotein 314;GA733-;GA733-2;gp4;gp40;Ly7;Ly74;lymphocyte antigen 74;mEGP314;panepithelial glycoprotein 314;protein 289A;Tacsd1;Tacst;Tacstd1;TR;Trop-1 protein;TROP1;tumor-associated calcium signal transducer 1
- Extra Details:
- Epithelial Cell Adhesion Molecule (EpCAM), also known as GA733-2 antigen, is a type I transmembrane glycoprotein composed of an extracellular domain with two EGF-Like repeats and a cystenin-rich region, a transmembrane domain and a cytoplasmic domain. It modulates cell adhesion and proliferation. Its overexpression has been detected in many epithelial tumours and has been associated with high stage, high grade and a worse survival in some tumour types. EpCAM has been shown to function as a calcium-independent homophilic cell adhesion molecule that does not exhibit any obvious relationship to the four known cell adhesion molecule superfamilies. However, recent insights have revealed that EpCAM participates in not only cell adhesion, but also in proliferation, migration and differentiation of cells. In addition, recent study revealed that EpCAM is the Wnt-beta-catenin signaling target gene and may be used to facilitate prognosis. It has oncogenic potential and is activated by release of its intracellular domain, which can signal into the cell nucleus by engagement of elements of the wnt pathway. None (Azide-Free,Low Endotoxin) are perfectly suited to be used in culture or in vivo (for nonhuman studies) for functional assays blocking, neutralizing, activation or depletion where the presence of azide may damage cells or exogenous endotoxin may signal or activate cells.
- Shipping Conditions:
- Blue Ice