APC Anti-Mouse CD150/SLAM Antibody[TC15-12F12.2]

Size

£72.90

Was £81.00

SKU:: E-AB-F1177E
Additional Names:: CD 150,Signaling lymphocytic activation molecule,Slam,Slamf1
Application:: Flow Cytometry
Storage Conditions:: 2-8[o]C Do not freeze. Protect from light.
Supplier:: Elabscience
Host:: Rat
Reactivities:: Mouse
Buffer:: PBS
Immunogen:: CD150/SLAM
Clone:: TC15-12F12.2
Uniprot:: Q9QUM4
Synonyms:: 4933415F16;AA177906;CD150;CDw150;ESTM5;ESTM51;IP;IPO-3;S;signaling lymphocyte activation molecule;signaling lymphocytic activation molecule;Slam;SLAM family member 1
Extra Details:: CD150 is a 75-95 kD member of the immunoglobulin superfamily, also known as SLAM (signaling lymphocyte activation molecule) or IPO-3. CD150, a single chain type I transmembrane molecule, is expressed on thymocytes, T cell subsets, B cells, dendritic cells, and endothelial cells. The expression is upregulated upon activation. CD150 expression has been shown to be maintained on Th1 but not Th2 clones. T regulatory cells express a relatively high level of CD150. Antibodies against CD150 have been shown to augment IFN-G Gamma production by Th1 cells, especially when co-stimulated through the TCR. CD150 associates with the src homology 2-domain-containing protein tyrosine phosphatase SHP-2, and this association is thought to be involved in signal transduction. In combination with CD48, CD150 is a useful marker for hematopoietic stem cell studies.