APC Anti-Human/Monkey CD61 Antibody[VI-PL2]

Size

£108.00

Was £120.00

SKU:: E-AB-F1166E
Additional Names:: GP3A,GPIIIa,ITGB3,Integrin beta-3
Application:: Flow Cytometry
Storage Conditions:: 2-8[o]C Do not freeze. Protect from light.
Supplier:: Elabscience
Host:: Mouse
Reactivities:: Human
Buffer:: PBS
Immunogen:: CD61
Clone:: VI-PL2
Uniprot:: P05106
Synonyms:: antigen CD61;BDPLT16;BDPLT2;BDPLT24;CD61;GP3A;GPIIIa;GT;GT2;integrin beta 3;integrin beta chain, beta 3;integrin beta-3;integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61);platelet membrane glycoprotein IIIa
Extra Details:: CD61, also known as integrin B Beta3 and glycoprotein IIIa (gpIIIa), is a 90 kD type I integral transmembrane glycoprotein. It is a member of the integrin family, associating with platelet gpIIb (CD41) to form CD41/CD61 complex and with integrin A AlphaV (CD51) to form A AlphaV/B Beta3 (CD51/CD61) integrin. CD41/CD61 is expressed on platelets and megakaryocytes, and plays a role in platelet activation and aggregation through interaction with fibrinogen, fibronectin, vWF, and other RGD-containing adhesion molecules. CD51/CD61 is expressed on platelets, osteoclasts, fibroblasts, macrophages, and some tumor cells involved in tumor metastasis, and in adenovirus infection through binding to RGD motif in extracellular matrix proteins.