APC Anti-Human/Monkey CD196/CCR6 Antibody[G034E3]

Size

£117.90

Was £131.00

SKU:: E-AB-F1158E
Additional Names:: CMKBR6,GPR29,STRL22,CKRL3,GPRCY4,CCR6
Application:: Flow Cytometry
Storage Conditions:: 2-8[o]C Do not freeze. Protect from light.
Supplier:: Elabscience
Host:: Mouse
Reactivities:: Human
Buffer:: PBS
Immunogen:: CD196/CCR6
Clone:: G034E3
Uniprot:: P51684
Synonyms:: BN-1;C-C chemokine receptor type 6;C-C CKR-6;CC-CKR-6;CCR-6;CD196;chemokine (C-C motif) receptor 6;chemokine (C-C) receptor 6;chemokine receptor-like 3;CKR-L3;CKRL3;CMKBR6;DCR2;DRY6;G protein-coupled receptor 29;G-protein coupled receptor 29;GPR-CY4;GPR29;GPRCY4;LARC receptor;seven-transmembrane receptor, lymphocyte, 22;STRL22
Extra Details:: CCR6, also known as CD196/CCR6, is a chemokine receptor that is expressed on immature dendritic cells, B lymphocytes, and memory T cells. CCR6 binds CCL20, although members of the B Beta defensin family also bind CCR6 with a lower affinity. CCR6 positive cells, and its ligand CCL20, have been detected in numerous organs, especially the secondary lymphoid organ. CCL20 is selectively made by the follicle-associated epithelium (FAE) overlying Peyers Patches (PPs) and isolated lymphoid follicles (ILFs). CCL20 contributes to the recruitment of CCR6-expressing B cells to these structures. In humans, CCR6 can function to mediate arrest of T cells on dermal endothelial cells and is highly expressed on T cells resident in both normal and psoriatic skin. CCR6 and/or CCL20 have been implicated in the pathogenesis of rheumatoid arthritis and inflammatory bowel disease. Human T cells that are able to produce IL-17 express CCR6. It suggests that CCL20 and CCR6 have a role in inflammatory diseases by recruiting Th17 cells to target tissues.

Shipping Conditions:: Blue Ice