PE Anti-Human CD127/IL-7RA Antibody[A019D5]

Size

£108.00

Was £120.00

SKU:: E-AB-F1152D
Additional Names:: CD127,CDw127,IL-7RA,IL-7RA Alpha,Interleukin-7 receptor subunit alpha
Application:: Flow Cytometry
Storage Conditions:: 2-8[o]C Do not freeze. Protect from light.
Supplier:: Elabscience
Host:: Mouse
Reactivities:: Human
Buffer:: PBS
Immunogen:: CD127
Clone:: A019D5
Uniprot:: P16871
Synonyms:: CD127;CD127 antigen;CDW127;IL-7 receptor subunit alpha;IL-7R subunit alpha;IL-7R-alpha;IL7RA;ILRA;interleukin 7 receptor alpha chain;interleukin-7 receptor subunit alpha
Extra Details:: CD127 is a 60-90 kD type I transmembrane glycoprotein also known as IL-7 receptor A Alpha chain or IL-7RA Alpha. It forms a heterodimer with the common G Gamma chain (G Gammac or CD132) which is shared with the receptors for IL-2, IL-4, IL-9, IL-13, IL-15, and IL-21. CD127 is expressed on immature B cells through early pre-B stage cells, thymocytes (except CD4/CD8 double positive thymocytes), peripheral T cells, and bone marrow stromal cells. CD127 has been reported to be a useful marker for identifying memory and effector T cells. Studies have shown that CD127 expression is down-modulated on Treg cells. It can be used as a marker for differentiation of Treg and conventional T cells. The ligation of IL-7 with its receptor is important for stimulation of mature and immature T cells as well as immature B cell proliferation and development.