APC Anti-Human/Monkey CD49d Antibody[9F10]

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£117.90

Was £131.00

SKU:: E-AB-F1144E
Additional Names:: CD49 antigen-like family member D,CD49d,ITGA4,Integrin alpha-4,Integrin alpha-IV,VLA-4 subunit alpha
Application:: Flow Cytometry
Storage Conditions:: 2-8[o]C Do not freeze. Protect from light.
Supplier:: Elabscience
Host:: Mouse
Reactivities:: Human
Buffer:: PBS
Immunogen:: CD49d
Clone:: 9F10
Uniprot:: P13612
Synonyms:: 269C wild type;alpha 4 subunit of VLA-4 receptor;antigen CD49D, alpha-4 subunit of VLA-4 receptor;CD49 antigen-like family member D;CD49D;IA4;integrin alpha-4;integrin alpha-IV;very late activation protein 4 receptor, alpha 4 subunit;VLA-4 subunit alpha
Extra Details:: CD49d is a 150 kD A Alpha integrin chain known as A Alpha4 integrin or VLA-4 A Alpha chain. It forms a heterodimer with either integrin B Beta1 (A Alpha4B Beta1, VLA-4) or B Beta7 (A Alpha4B Beta7). CD49d is expressed broadly on T lymphocytes, B lymphocytes, monocytes, thymocytes, eosinophils, basophils, mast cells, NK cells, dendritic cells, and some non-hematopoietic cells, but not on normal red blood cells, platelets or neutrophils. VLA-4 binds to VCAM-1 (CD106) and fibronectin. A Alpha4B Beta7 is the receptor for VCAM-1 and MAdCAM-1. CD49d participates in mononuclear cell trafficking to endothelial sites of inflammation and has roles in cell-cell interactions and cell adhesion to extracellular matrices. CD49d is involved in lymphocyte migration, T cell activation, and hematopoietic stem cell differentiation. CD49d is a marker to isolate pure populations of Treg cells due to its absence on Foxp3+ cells.

Shipping Conditions:: Blue Ice