E-AB-F1133E
APC Anti-Human CD274/PD-L1 Antibody[29E.2A3]
Size
£108.00
Was £120.00
- SKU:
- E-AB-F1133E
- Additional Names:
- B7H1PD-L1PDCD1L1PDCD1LG1PDL1,B7 homolog 1,B7-H,B7-H1,Programmed cell death ligand 1
- Application:
- Flow Cytometry
- Storage Conditions:
- 2-8[o]C Do not freeze. Protect from light.
- Supplier:
- Elabscience
- Host:
- Mouse
- Reactivities:
- Human
- Buffer:
- PBS
- Immunogen:
- CD274/PD-L1
- Clone:
- 29E.2A3
- Uniprot:
- Q9NZQ7
- Synonyms:
- B7 homolog 1;B7-H;B7H1;CD274 antigen;hPD-L1;PD-L1;PDCD1 ligand 1;PDCD1L1;PDCD1LG1;PDL1;programmed cell death 1 ligand 1
- Extra Details:
- CD274, also known as PD-L1 and B7-H1, is type I transmembrane glycoprotein that serves as a ligand for CD279 (PD-1). This interaction is believed to regulate the balance between the stimulatory and inhibitory signals needed for responses to microbes and maintenance of self-tolerance. CD274 is involved in the costimulation of T cell proliferation and IL-10 and IFN-G Gamma production in an IL-2-dependent and CD279-independent manner. Conflicting data has shown that CD274 can inhibit T cell proliferation and cytokine production, and alternatively, enhance T cell activation. Other studies suggest that CD274 may signal bidirectionally, raising interesting implications for its expression in a wide variety of cell types, including T and B cells, antigen-presenting cells, and nonhematopoietic cells.
- Shipping Conditions:
- Blue Ice