APC Anti-Mouse CD119 Antibody[GR-20]

Size

£130.50

Was £145.00

SKU:: E-AB-F1115E
Additional Names:: CD119,IFN-gamma-R-alpha,IFN-gamma-R1,Ifngr1,Interferon gamma receptor 1
Application:: Flow Cytometry
Storage Conditions:: 2-8[o]C Do not freeze. Protect from light.
Supplier:: Elabscience
Host:: Rat
Reactivities:: Mouse
Buffer:: PBS
Immunogen:: CD119
Clone:: GR-20
Uniprot:: P15261
Synonyms:: CD119;If;Ifgr;IFN-g;IFN-gamma receptor 1;IFN-gamma-R-alpha;IFN-gamma-R1;IFN-gammaR;Ifngr;INF-g receptor;interferon gamma receptor 1;interferon gamma receptor alpha-chain;Nk;Nktar
Extra Details:: CDw119 is a 90 kD immunoglobulin superfamily member, also known as IFN-G GammaRA Alpha chain. It is a class II cytokine receptor family member that serves as a IFN-G Gamma-binding chain associated with the IFN-G Gamma B Beta chain also known as AF-1. In addition to ligand binding, CDw119 participates in ligand trafficking. CDw119 is expressed on T and B cells, NK cells, fibroblasts, endothelial, and epithelial cells. Binding of IFN-G Gamma induces receptor dimerization, internalization, Jak1 and Jak2 protein kinase activation and, ultimately, STAT1 activation. IFN-G Gamma initiates and regulates a variety of immune responses.