Elab Fluor[R] 700 Anti-Mouse CD45R/B220 Antibody[RA3.3A 1/6.1]

Size

£83.70

Was £93.00

SKU:: E-AB-F1112M1
Additional Names:: B220
Application:: Flow Cytometry
Storage Conditions:: 2-8[o]C Do not freeze. Protect from light.
Supplier:: Elabscience
Host:: Rat
Reactivities:: Mouse
Buffer:: PBS
Immunogen:: CD45R/B220
Clone:: RA3.3A 1/6.1
Uniprot:: P06800, P08575
Synonyms:: B220;CD45;CD45 antigen;CD45R;GP180;L-CA;LCA;leukocyte common antigen;loc;Ly-;Ly-5;LY5;lymphocyte antigen 5;lymphocyte common antigen;Lyt-;Lyt-4;protein tyrosine phosphatase, receptor type, c polypeptide;receptor-type tyrosine-protein phosphatase C;T200;T200 glycoprotein;T200 leukocyte common antigen
Extra Details:: CD45R, also known as B220, is an isoform of CD45. It is a member of the protein tyrosine phosphatase (PTP) family with a molecular weight of approximately 180-240 kD. CD45R is expressed on B cells (at all developmental stages from pro-B cells through mature B cells), activated B cells, and subsets of T and NK cells. CD45R (B220) is also expressed on a subset of abnormal T cells involved in the pathogenesis of systemic autoimmunity in MRL-Faslpr and MRL-Fasgld mice. It plays a critical role in TCR and BCR signaling. The primary ligands for CD45 are galectin-1, CD2, CD3, and CD4. CD45R is commonly used as a pan-B cell marker, however, CD19 may be more appropriate for B cell specificity.