Purified Anti-Mouse CD115/CSF-1R Antibody[AFS98], Functional Grade

Size

£80.10

Was £89.00

SKU:: E-AB-F11070
Additional Names:: CD115,CSF-1 receptor (EC:2.7.10.1),CSF-1-R,CSF-1R,Csf1r,Csfmr,Fms,M-CSF-R,Macrophage colony-stimulating factor 1 receptor,Proto-oncogene c-Fms
Application:: Flow Cytometry
Concentration:: >= 1 mg/ml
Purification:: protein a/g purified
Storage Conditions:: 2-8[o]C Avoid freeze/thaw cycles., -20[o]C Avoid freeze/thaw cycles.
Supplier:: Elabscience
Host:: Rat
Reactivities:: Mouse
Buffer:: Sterile PBS, pH 7.2. < 1.0 EU per mg of the antibody as determined by the LAL method.
Immunogen:: Recombinant Mouse CD115 protein
Clone:: AFS98
Uniprot:: P09581
Synonyms:: AI323359;c-fms;CD115;Csf;CSF-;CSF-1 receptor;CSF-1-R;CSF-1R;Csfmr;Fim;Fim-;Fim-2;Fim2;Fm;Fms;M-CS;M-CSF-R;M-CSFR;macrophage colony-stimulating factor 1 receptor;proto-oncogene c-Fms;proto-oncogene fms
Extra Details:: CSF-1R, also known as CD115 and M-CSFR, is a single-pass type I membrane protein and member of the platelet-derived growth factor receptor family. This c-fms (Fms proto-oncogene) gene product's natural ligands include M-CSF and IL-34. Structural studies of CD115 have described an Ig-like extracellular domain, a transmembrane domain, an intracellular juxtamembrane domain, a split tyrosine kinase domain, and a C-terminal tail receptor. Receptor activation induces homodimerization in addition to phosphorylation and ubiquitination of intracellular residues. CD115 directly influences tissue macrophage and osteoclast differentiation and proliferation. It is expressed on monocytes/macrophages, peritoneal exudate cells, plasmacytoid and conventional dendritic cells, and osteoclasts. None (Azide-Free,Low Endotoxin) are perfectly suited to be used in culture or in vivo (for nonhuman studies) for functional assays blocking, neutralizing, activation or depletion where the presence of azide may damage cells or exogenous endotoxin may signal or activate cells.

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