Purified Anti-Mouse CD8a Antibody[53-6.7], Functional Grade

Size

£80.10

Was £89.00

SKU:: E-AB-F11040
Additional Names:: CD8A,MAL,T-cell surface glycoprotein CD8 alpha chain,T-lymphocyte differentiation antigen T8/Leu-2
Application:: Flow Cytometry
Concentration:: >= 1 mg/ml
Purification:: protein a/g purified
Storage Conditions:: 2-8[o]C Avoid freeze/thaw cycles., -20[o]C Avoid freeze/thaw cycles.
Supplier:: Elabscience
Host:: Rat
Reactivities:: Mouse
Buffer:: Sterile PBS, pH 7.2. < 1.0 EU per mg of the antibody as determined by the LAL method.
Immunogen:: Recombinant Mouse CD8a protein
Clone:: 53-6.7
Uniprot:: P01731
Synonyms:: BB154331;Ly-;Ly-2;Ly-3;Ly-35;Ly-B;Lyt-;Lyt-2;Lyt-2.1 lymphocyte differentiation antigen (AA at 100);T-cell surface glycoprotein CD8 alpha chain;T-cell surface glycoprotein Lyt-2
Extra Details:: CD8, also known as Lyt-2, Ly-2, or T8, consists of disulfide-linked A Alpha and B Beta chains that form the A Alpha(CD8a)/B Beta(CD8b) heterodimer and A Alpha/A Alpha homodimer. CD8a is a 34 kD protein that belongs to the immunoglobulin family. The CD8 A Alpha/B Beta heterodimer is expressed on the surface of most thymocytes and a subset of mature TCR A Alpha/B Beta T cells. CD8 expression on mature T cells is non-overlapping with CD4. The CD8 A Alpha/A Alpha homodimer is expressed on a subset of G Gamma/D Delta TCR-bearing T cells, NK cells, intestinal intraepithelial lymphocytes, and lymphoid dendritic cells. CD8 is an antigen co-receptor on T cells that interacts with MHC class I on antigen-presenting cells or epithelial cells. CD8 promotes T cell activation through its association with the TCR complex and protein tyrosine kinase lck. None (Azide-Free,Low Endotoxin) are perfectly suited to be used in culture or in vivo (for nonhuman studies) for functional assays blocking, neutralizing, activation or depletion where the presence of azide may damage cells or exogenous endotoxin may signal or activate cells.

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