PE Anti-Mouse CD103 Antibody[M290]

Size

£116.10

Was £129.00

SKU:: E-AB-F1090D
Additional Names:: CD103,Integrin alpha M290,Integrin alpha-E,Itgae
Application:: Flow Cytometry
Storage Conditions:: 2-8[o]C Do not freeze. Protect from light.
Supplier:: Elabscience
Host:: Rat
Reactivities:: Mouse
Buffer:: PBS
Immunogen:: CD103
Clone:: M290
Uniprot:: Q60677
Synonyms:: A530055J10;alph;alpha-E1;alpha-M290;aM290;CD103;integrin alpha M290;integrin alpha-E
Extra Details:: CD103 is a type I transmembrane glycoprotein known as A AlphaE integrin or Integrin A AlphaIEL chain. It belongs to the integrin family and is primarily found on intestinal intraepithelial lymphocytes (IEL). CD103 is also expressed on a subpopulation of lamina propria T cells, epithelial dendritic cells, lamina propria-derived dendritic cells, and a small subset of peripheral lymphocytes. T regulatory cells express high level of CD103. The CD103 expression on lymphocytes can be induced upon activation and TGF-B Beta stimulation. In association with integrin B Beta7, CD103 is expressed as A AlphaE/B Beta7 heterodimer. Mature CD103 protein can be cleaved into 2 chains, a 150 kD (C-terminal) chain and a 25 kD (N-terminal) chain, which remain linked by disulfide bonds. CD103 binds to E-cadherin and mediates homing of lymphocytes to the intestinal epithelium.