PE Anti-Human CD40 Antibody[3A8]

Size

£90.90

Was £101.00

SKU:: E-AB-F1037D
Additional Names:: B-cell surface antigen CD40,Bp50,CD40,CD40L receptor,Cd40,Tnfrsf5,Tumor necrosis factor receptor superfamily member 5
Application:: Flow Cytometry
Storage Conditions:: 2-8[o]C Do not freeze. Protect from light.
Supplier:: Elabscience
Host:: Mouse
Reactivities:: Human
Buffer:: PBS
Immunogen:: CD40
Clone:: 3A8
Uniprot:: P25942
Synonyms:: B cell surface antigen CD40;B cell-associated molecule;B-cell surface antigen CD40;Bp50;CD40 molecule, TNF receptor superfamily member 5;CD40L receptor;CDW40;p50;TNFRSF5;tumor necrosis factor receptor superfamily member 5
Extra Details:: CD40 is a 48 kD type I glycoprotein also known as BP50. It is a member of the TNFR superfamily primarily expressed on B cells, macrophages, follicular dendritic cells, endothelial cells, fibroblasts, and at low levels on plasma cells. CD40 has been reported to be involved in B cell differentiation, costimulation, isotype class-switching, and protection of B cells from apoptosis. Additionally, CD40 is important for T cell-B cell interactions. The ligand of CD40 is CD154 (CD40 ligand). The 5C3 antibody has been reported to promote B cell proliferation in the presence of anti-IgM, IL-4 or PMA, partially blocking CD40 binding to CD40L, and B cells rescue from apoptosis.