Purified Anti-Mouse CD122/IL-2RB Antibody[5H4], Functional Grade

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£80.10

Was £89.00

SKU:: E-AB-F10290
Additional Names:: IL-2R subunit beta,CD122,High affinity IL-2 receptor subunit beta,IL-2 receptor subunit beta,IL-2RB,Il2rb,Interleukin-2 receptor subunit beta,p70-75
Application:: Flow Cytometry
Concentration:: >= 1 mg/ml
Purification:: protein a/g purified
Storage Conditions:: 2-8[o]C Avoid freeze/thaw cycles., -20[o]C Avoid freeze/thaw cycles.
Supplier:: Elabscience
Host:: Rat
Reactivities:: Mouse
Buffer:: Sterile PBS, pH 7.2. < 1.0 EU per mg of the antibody as determined by the LAL method.
Immunogen:: Recombinant Mouse CD122 protein
Clone:: 5H4
Uniprot:: P16297
Synonyms:: CD122;high affinity IL-2 receptor subunit beta;IL-15 receptor beta chain;IL-15R;IL-15Rbeta;IL-2 receptor beta chain;IL-2 receptor subunit beta;IL-2/15 receptor-beta;Il-2/15Rbeta;Il-2R;IL-2R subunit beta;IL-2RB;Il-2Rbeta;IL15R;IL15Rbeta;interleukin-2 receptor subunit beta;p70;p70-75
Extra Details:: CD122 is a 70-75 kD IL-2 receptor B Beta chain also known as IL-2RB Beta, which is also shared by the IL-15 receptor. It is constitutively expressed by NK cells and at lower levels by T cells, B cells, monocytes, and macrophages. The IL-2RB Beta chain can combine with either the common G Gamma subunit (G Gammac, CD132) alone or with the G Gammac subunit and the IL-2RA Alpha subunit (CD25) to generate intermediate or high affinity IL-2 receptor complexes, respectively. CD122 expression levels can be upregulated by activation. The 5H4 antibody does not block IL-2 binding to the IL-2 receptor. CD122 is expressed on murine, but not human, CD8+ Tregs involved in the maintenance of T cell homeostasis. None (Azide-Free,Low Endotoxin) are perfectly suited to be used in culture or in vivo (for nonhuman studies) for functional assays blocking, neutralizing, activation or depletion where the presence of azide may damage cells or exogenous endotoxin may signal or activate cells.

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