APC Anti-Mouse CD22 Antibody[Cy34.1]

Size

£90.90

Was £101.00

SKU:: E-AB-F1021E
Additional Names:: Siglec2,B-cell receptor CD22,B-lymphocyte cell adhesion molecule,BL-CAM,CD22,Cd22,Lyb-8,Sialic acid-binding Ig-like lectin 2,Siglec-2,T-cell surface antigen Leu-14
Application:: Flow Cytometry
Storage Conditions:: 2-8[o]C Do not freeze. Protect from light.
Supplier:: Elabscience
Host:: Mouse
Reactivities:: Mouse
Buffer:: PBS
Immunogen:: CD22
Clone:: Cy34.1
Uniprot:: P35329
Synonyms:: A530093D23;B-cell receptor CD22;B-lymphocyte cell adhesion molecule;BL-CAM;Lyb;Lyb-;Lyb-8;Lyb8;sialic acid-binding Ig-like lectin 2;siglec-2;T-cell surface antigen Leu-14
Extra Details:: The Cy34.1 monoclonal antibody specifically binds to the B-lymphocyte differentiation antigen CD22 on strains having the Lyb-8.2 alloantigen (e.g., A, BALB/c, CBA, C3H/He, C57BL, C57L, C58, SJL, SWR, but not AKR, DBA/1, DBA/2, NZB, PL). CD22 is expressed at high levels on mature peripheral B lymphocytes (follicular and marginal zone), B-1 cells (CD5+ B cells), and plasma cells. It is a member of the Ig gene superfamily and associates with the B-cell antigen receptor. Its sialic acid- binding immunoglobulin-like lectin (siglec) extracellular region mediates B-cell adhesion to ligands on endothelial cells in the bone marrow. Its intracellular domain is phosphorylated after cross-linking of antigen receptor or MHC class II antigen. It is involved in negative regulation of B-cell activation and protection from autoimmunity. B-cell proliferative responses to LPS or anti-mouse Ig u chain are augmented in the presence of Cy34.1 mAb.

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