APC Anti-Mouse CD54 Antibody[YN1/1.7.4]

Size

£60.30

Was £67.00

SKU:: E-AB-F1018E
Additional Names:: CD54,Icam-1,Icam1,Intercellular adhesion molecule 1,MALA-2,MyD10
Application:: Flow Cytometry
Storage Conditions:: 2-8[o]C Do not freeze. Protect from light.
Supplier:: Elabscience
Host:: Rat
Reactivities:: Mouse
Buffer:: PBS
Immunogen:: CD54
Clone:: YN1/1.7.4
Uniprot:: P13597
Synonyms:: CD54;Icam;Icam-1;intercellular adhesion molecule 1;Ly-4;Ly-47;MAL;MALA-2;myD10
Extra Details:: CD54 is a 90 kD immunoglobulin superfamily member also known as ICAM-1 and Ly-47. It is expressed on activated endothelial cells, high endothelial venules (HEV), T and B cells, monocytes/ macrophages, granulocytes, and dendritic cells. CD54 is an important intracellular adhesion molecule that participates in T cell-T cell, T cell-B cell, and T cell-target cell interactions via binding of LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18). CD54 has also been shown to be involved in lymphocyte trafficking, making it an important molecule in many immune reactions and inflammation. CD54 is also a receptor for rhinovirus. The YN1/1.7.4 antibody has been reported to block binding of mouse CD54 to LFA-1 and Mac-1, inhibit cell-cell adhesion, and function in antigen presentation to T cells and leukocyte migration to inflammatory tissues.