E-AB-93380
NR3C2 Polyclonal Antibody
Size
£195.30
Was £217.00
- SKU:
- E-AB-93380
- Additional Names:
- MCR,MLR,MR,NR3C2,NR3C2VIT
- Application:
- IHC, WB, IF
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Recombinant fusion protein of human Mineralocorticoid receptor
- Uniprot:
- P08235
- Synonyms:
- aldosterone receptor;MCR;mineralocorticoid receptor;mineralocorticoid receptor 1;mineralocorticoid receptor 2;mineralocorticoid receptor delta;MLR;MR;NR3C2VIT;Nuclear receptor subfamily 3 group C member 2;nuclear receptor subfamily 3, group C, member 2 variant 3
- Extra Details:
- This gene encodes the mineralocorticoid receptor, which mediates aldosterone actions on salt and water balance within restricted target cells. The protein functions as a ligand-dependent transcription factor that binds to mineralocorticoid response elements in order to transactivate target genes. Mutations in this gene cause autosomal dominant pseudohypoaldosteronism type I, a disorder characterized by urinary salt wasting. Defects in this gene are also associated with early onset hypertension with severe exacerbation in pregnancy. Alternative splicing results in multiple transcript variants.
- Shipping Conditions:
- Blue Ice