E-AB-93354
NLRP3 Polyclonal Antibody
Size
£195.30
Was £217.00
- SKU:
- E-AB-93354
- Additional Names:
- AGTAVPRL, AVP, C1orf7, CIAS1, CLR1.1, DFNA34, FCAS, FCAS1, FCU, KEFH, MWS, NALP3, PYPAF1,AII
- Application:
- WB, IF
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Recombinant fusion protein of mouse NLRP3
- Uniprot:
- Q8R4B8
- Synonyms:
- AGTAVPRL;AII/AVP;Ci;Cias1;cold autoinflammatory syndrome 1 protein homolog;cry;cryopyrin;FCAS;FCU;mast cell maturation-associated-inducible protein 1;Mmig;Mmig1;MWS;N;NACHT, LRR and PYD domains-containing protein 3;NACHT/LRR/pyrin domain-containing protein 3;NALP3;Pyp;Pypaf1;PYRIN-containing APAF1-like protein 1
- Extra Details:
- This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NLRP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. The SARS-CoV 3a protein, a transmembrane pore-forming viroporin, has been shown to activate the NLRP3 inflammasome via the formation of ion channels in macrophages. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, neonatal-onset multisystem inflammatory disease (NOMID), keratoendotheliitis fugax hereditarian, and deafness, autosomal dominant 34, with or without inflammation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data, however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid.
- Shipping Conditions:
- Blue Ice