E-AB-93321
TFEB Polyclonal Antibody
Size
£195.30
Was £217.00
- SKU:
- E-AB-93321
- Additional Names:
- ALPHATFEB,BHLHE35,TCFEB,TFEB
- Application:
- IHC, WB, IF
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Recombinant fusion protein of human TFEB
- Uniprot:
- P34897
- Synonyms:
- epididymis secretory sperm binding protein Li 51e;GLY A+;GLYA;glycine auxotroph A, human complement for hamster;glycine hydroxymethyltransferase;HEL-S-51e;NEDCASB;serine aldolase;serine hydroxymethylase;serine hydroxymethyltransferase 2 (mitochondrial);serine hydroxymethyltransferase, mitochondrial;serine methylase;SHMT;threonine aldolase
- Extra Details:
- Transcription factor that acts as a master regulator of lysosomal biogenesis, autophagy, lysosomal exocytosis, lipid catabolism, energy metabolism and immune response. Specifically recognizes and binds E-box sequences (5'-CANNTG-3', efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. Involved in the cellular response to amino acid availability by acting downstream of MTOR: in the presence of nutrients, TFEB phosphorylation by MTOR promotes its cytosolic retention and subsequent inactivation. Upon starvation or lysosomal stress, inhibition of MTOR induces TFEB dephosphorylation, resulting in nuclear localization and transcription factor activity.
- Shipping Conditions:
- Blue Ice