E-AB-93263
S100A8 Polyclonal Antibody
Size
£195.30
Was £217.00
- SKU:
- E-AB-93263
- Additional Names:
- 60B8A, 60B8Ag, AI323541, B8A, B8Ag, CFA, CFAg, CP-1, CP-10, Ca, Caga, MR, MRP8, p8,p
- Application:
- IHC, WB
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Recombinant fusion protein of mouse S100A8
- Uniprot:
- P27005
- Synonyms:
- 60B8A;60B8Ag;AI323541;B8A;B8Ag;Ca;Caga;calgranulin-A;CFA;CFAg;chemotactic cytokine CP-10;chemotactic S100 protein;CP-1;CP-10;leukocyte L1 complex light chain;migration inhibitory factor-related protein 8;MR;MRP-8;MRP8;p;p8;pro-inflammatory S100 cytokine;protein S100-A8;S100 calcium-binding protein A8
- Extra Details:
- S100A8 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis and adhesion. Predominantly found as calprotectin (S100A8/A9 which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase. Activates NADPH-oxidase by facilitating the enzyme complex assembly at the cell membrane, transferring arachidonic acid, an essential cofactor, to the enzyme complex and S100A8 contributes to the enzyme assembly by directly binding to NCF2/P67PHOX. The extracellular functions involve proinflammatory, antimicrobial, oxidant-scavenging and apoptosis-inducing activities.
- Shipping Conditions:
- Blue Ice