E-AB-93136
GPR109A/HM74A/HCAR2 Polyclonal Antibody
Size
£195.30
Was £217.00
- SKU:
- E-AB-93136
- Additional Names:
- GPR109A,HCA2,HCAR2,HM74a,HM74b,NIACR1,PUMAG,Puma-g
- Application:
- IHC, WB
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- A synthetic peptide of human GPR109A/HM74A/HCAR2
- Uniprot:
- Q8TDS4
- Synonyms:
- G protein-coupled receptor HM74a;G-protein coupled receptor 109A;G-protein coupled receptor HM74A;GPR109A;HCA2;HM74a;HM74b;hydroxy-carboxylic acid receptor 2;hydroxycarboxylic acid receptor 2;niacin receptor 1;NIACR1;nicotinic acid receptor;Puma-g;PUMAG
- Extra Details:
- Acts as a high affinity receptor for both nicotinic acid (also known as niacin and (D-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide.
- Shipping Conditions:
- Blue Ice