E-AB-92941
ARC Polyclonal Antibody
Size
£195.30
Was £217.00
- SKU:
- E-AB-92941
- Additional Names:
- ARC,Arg3.1
- Application:
- WB
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Recombinant fusion protein of human ARC
- Uniprot:
- Q7LC44
- Synonyms:
- activity-regulated cytoskeleton-associated protein;activity-regulated gene 3.1 protein homolog;ARC/ARG3.1;Arg3.1;hArc
- Extra Details:
- Master regulator of synaptic plasticity that self-assembles into virion-like capsids that encapsulate RNAs and mediate intercellular RNA transfer in the nervous system. ARC protein is released from neurons in extracellular vesicles that mediate the transfer of ARC mRNA into new target cells, where ARC mRNA can undergo activity-dependent translation. ARC capsids are endocytosed and are able to transfer ARC mRNA into the cytoplasm of neurons. Acts as a key regulator of synaptic plasticity: required for protein synthesis-dependent forms of long-term potentiation (LTP and depression (LTD and for the formation of long-term memory.
- Shipping Conditions:
- Blue Ice