E-AB-92937
CLPB Polyclonal Antibody
Size
£195.30
Was £217.00
- SKU:
- E-AB-92937
- Additional Names:
- ANKCLB,CLPB,HSP78,MEGCANN,MGCA7,SKD3
- Application:
- WB
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Recombinant fusion protein of human CLPB
- Uniprot:
- Q9H078
- Synonyms:
- ANKCLB;ankyrin-repeat containing bacterial clp fusion;caseinolytic peptidase B protein homolog;ClpB caseinolytic peptidase B homolog;ClpB homolog, mitochondrial AAA ATPase chaperonin;HSP78;MEGCANN;MGCA7;SKD3;suppressor of potassium transport defect 3;testicular secretory protein Li 11
- Extra Details:
- This gene belongs to the ATP-ases associated with diverse cellular activities (AAA+) superfamily. Members of this superfamily form ring-shaped homo-hexamers and have highly conserved ATPase domains that are involved in various processes including DNA replication, protein degradation and reactivation of misfolded proteins. All members of this family hydrolyze ATP through their AAA+ domains and use the energy generated through ATP hydrolysis to exert mechanical force on their substrates. In addition to an AAA+ domain, the protein encoded by this gene contains a C-terminal D2 domain, which is characteristic of the AAA+ subfamily of Caseinolytic peptidases to which this protein belongs. It cooperates with Hsp70 in the disaggregation of protein aggregates. Allelic variants of this gene are associated with 3-methylglutaconic aciduria, which causes cataracts and neutropenia. Alternative splicing results in multiple transcript variants.
- Shipping Conditions:
- Blue Ice