E-AB-92695
CNOT1 Polyclonal Antibody
Size
£195.30
Was £217.00
- SKU:
- E-AB-92695
- Additional Names:
- AD-005,CDC39,CNOT1,NOT1,NOT1H
- Application:
- WB, IF
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Recombinant fusion protein of human CNOT1
- Uniprot:
- A5YKK6
- Synonyms:
- AD-005;adrenal gland protein AD-005;CCR4-associated factor 1;CCR4-NOT transcription complex subunit 1;CDC39;HPE12;negative regulator of transcription subunit 1 homolog;NOT1;NOT1 (negative regulator of transcription 1, yeast) homolog;NOT1H;VIBOS
- Extra Details:
- Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Involved in degradation of AU-rich element (ARE-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of embryonic stem (ES cell identity.
- Shipping Conditions:
- Blue Ice