E-AB-92639
PIAS4 Polyclonal Antibody
Size
£195.30
Was £217.00
- SKU:
- E-AB-92639
- Additional Names:
- PIAS-gamma,PIAS4,PIASY,Piasg,ZMIZ6
- Application:
- WB
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Recombinant fusion protein of human PIAS4
- Uniprot:
- Q8N2W9
- Synonyms:
- E3 SUMO-protein ligase PIAS4;PIAS-gamma;Piasg;PIASY;protein inhibitor of activated STAT protein 4;protein inhibitor of activated STAT protein gamma;protein inhibitor of activated STAT protein PIASy;RING-type E3 ubiquitin transferase PIAS4;zinc finger, MIZ-type containing 6;ZMIZ6
- Extra Details:
- Functions as an E3-type small ubiquitin-like modifier (SUMO ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53/TP53 pathway, the Wnt pathway and the steroid hormone signaling pathway. Involved in gene silencing. Mediates sumoylation of CEBPA, PARK7, HERC2, MYB, TCF4 and RNF168. In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation.
- Shipping Conditions:
- Blue Ice