NKX2-1 Polyclonal Antibody

Size

£195.30

Was £217.00

SKU:: E-AB-92513
Additional Names:: BCH,BHC,NK-2,NKX2-1,NKX2.1,NKX2A,NMTC1,T/EBP,TEBP,TITF1,TTF-1,TTF1
Application:: WB
Concentration:: 1 mg/ml
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Avoid freeze/thaw cycles.
Supplier:: Elabscience
Host:: Rabbit
Reactivities:: Human, Rat
Buffer:: Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Immunogen:: Recombinant fusion protein of human NKX2-1
Uniprot:: P43699
Synonyms:: BCH;BHC;homeobox protein NK-2 homolog A;homeobox protein Nkx-2.1;NK-2;NK-2 homolog A;NKX2.1;NKX2A;NMTC1;T/EBP;TEBP;thyroid nuclear factor 1;thyroid transcription factor 1;thyroid-specific enhancer-binding protein;TITF1;TTF-1;TTF1
Extra Details:: This gene encodes a protein initially identified as a thyroid-specific transcription factor. The encoded protein binds to the thyroglobulin promoter and regulates the expression of thyroid-specific genes but has also been shown to regulate the expression of genes involved in morphogenesis. Mutations and deletions in this gene are associated with benign hereditary chorea, choreoathetosis, congenital hypothyroidism, and neonatal respiratory distress, and may be associated with thyroid cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares the symbol/alias 'TTF1' with another gene, transcription termination factor 1, which plays a role in ribosomal gene transcription.