E-AB-92358
TTLL12 Polyclonal Antibody
Size
£195.30
Was £217.00
- SKU:
- E-AB-92358
- Additional Names:
- dJ526I14.2, tubulin tyrosine ligase like 12,TTLL12
- Application:
- WB
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Recombinant fusion protein of human TTLL12
- Uniprot:
- Q14166
- Synonyms:
- dJ526I14.2;inactive tubulin--tyrosine ligase-like protein 12;tubulin tyrosine ligase-like family, member 12;tubulin--tyrosine ligase-like protein 12
- Extra Details:
- Negatively regulates post-translational modifications of tubulin, including detyrosination of the C-terminus and polyglutamylation of glutamate residues. Also, indirectly promotes histone H4 trimethylation at 'Lys-20' (H4K20me3. Probably by controlling tubulin and/or histone H4 post-translational modifications, plays a role in mitosis and in maintaining chromosome number stability. During RNA virus-mediated infection, acts as a negative regulator of the DDX58/RIG-I pathway by preventing MAVS binding to TBK1 and IKBKE.
- Shipping Conditions:
- Blue Ice