E-AB-92205
EPHA3/EPHA4/EPHA5 Polyclonal Antibody
Size
£195.30
Was £217.00
- SKU:
- E-AB-92205
- Additional Names:
- AW492086,Cek4,EC 2.7.10.1,EK4,End3,Eph receptor A3,EPH-like kinase 4,EPH-like tyrosine kinase 1,EPHA3,EPHA3,Ephrin receptor EphA3,Ephrin type-A receptor 3,ETK 1,ETK,ETK1,HEK 4,HEK,HEK4,Human embryo kinase 1,Human embryo kinase,Mek4,MGC109882,Receptor tyro
- Application:
- IHC, IF
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- A synthetic peptide of human EPHA3/EPHA4/EPHA5
- Uniprot:
- P29320, P54756, P54764
- Synonyms:
- brain-specific kinase;CEK7;EHK-1;EHK1;EK4;EK7;EK8;EPH homology kinase 1;EPH-like kinase 4;EPH-like kinase 7;EPH-like kinase 8;eph-like tyrosine kinase 1;ephrin type-A receptor 3;ephrin type-A receptor 4;ephrin type-A receptor 5;epididymis secretory sperm binding protein;ETK;ETK1;HEK;HEK4;HEK7;HEK8;human embryo kinase 1;receptor protein-tyrosine kinase HEK7;receptor protein-tyrosine kinase HEK8;SEK;testicular tissue protein Li 64;TYRO1;TYRO1 protein tyrosine kinase;TYRO4;TYRO4 protein tyrosine kinase;tyrosine-protein kinase receptor EHK-1;tyrosine-protein kinase receptor ETK1;tyrosine-protein kinase receptor SEK;tyrosine-protein kinase TYRO1;Tyrosine-protein kinase TYRO4
- Extra Details:
- Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in cardiac cells migration and differentiation and regulates the formation of the atrioventricular canal and septum during development probably through activation by EFNA1. Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development.
- Shipping Conditions:
- Blue Ice