E-AB-92158
SCAF8 Polyclonal Antibody
Size
£195.30
Was £217.00
- SKU:
- E-AB-92158
- Additional Names:
- RBM16,SCAF8
- Application:
- WB
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Recombinant fusion protein of human SCAF8
- Uniprot:
- Q9UPN6
- Synonyms:
- CDC5L complex-associated protein 7;protein SCAF8;RBM16;RNA-binding motif protein 16;SR-like CTD-associated factor 8;SR-related and CTD-associated factor 8
- Extra Details:
- Anti-terminator protein required to prevent early mRNA termination during transcription. Together with SCAF4, acts by suppressing the use of early, alternative poly(A sites, thereby preventing the accumulation of non-functional truncated proteins. Mechanistically, associates with the phosphorylated C-terminal heptapeptide repeat domain (CTD of the largest RNA polymerase II subunit (POLR2A, and subsequently binds nascent RNA upstream of early polyadenylation sites to prevent premature mRNA transcript cleavage and polyadenylation. Independently of SCAF4, also acts as a positive regulator of transcript elongation.
- Shipping Conditions:
- Blue Ice