E-AB-91948
Enpp1 Polyclonal Antibody
Size
£195.30
Was £217.00
- SKU:
- E-AB-91948
- Additional Names:
- 4833416E15Rik,AI428932,C76301,CD203c,E-NPP 1,E-NPP1,Enpp1,Ly-41,M6S1,NPP1,Npps,PC-1,Pca,Pca-1,Pdnp1,ttw,twy
- Application:
- WB, IF
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Recombinant fusion protein of mouse Enpp1
- Uniprot:
- G3X9S2
- Synonyms:
- 4833416E15Rik;AI428932;C76301;CD203c;E-N;E-NPP 1;E-NPP1;ectonucleotide pyrophosphatase/phosphodiesterase family member 1;Ly-4;Ly-41;lymphocyte antigen 41;M6S1;N;NPP1;Npps;P;PC-;PC-1;Pca;Pca-1;Pd;Pdnp1;phosphodiesterase I/nucleotide pyrophosphatase 1;plasma-cell membrane glycoprotein PC-1;tiptoe walking;ttw;twy
- Extra Details:
- This gene encodes a member of the nucleoside pyrophosphatase/phosphodiesterase family of enzymes that catalyzes the hydrolysis of pyrophosphate and phosphodiester bonds in nucleotide triphosphates and oligonucleotides, respectively, to generate nucleoside 5'-monophosphates. The encoded protein is a type II transmembrane glycoprotein that negatively regulates bone mineralization. Mice harboring a nonsense mutation in this gene, termed tiptoe walking (ttw), exhibit ectopic ossification of the spinal ligaments. The encoded protein binds to the insulin receptor, inhibits downstream signaling events and induces insulin resistance and glucose tolerance. This gene is located adjacent to a paralog on chromosome 10. Alternative splicing results in multiple transcript variants encoding different isoforms.
- Shipping Conditions:
- Blue Ice