NLRP10 Polyclonal Antibody

Size

£195.30

Was £217.00

SKU:: E-AB-91385
Additional Names:: CLR11.1,NALP10,NLRP10,NOD8,PAN5,PYNOD
Application:: WB
Concentration:: 1 mg/ml
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Avoid freeze/thaw cycles.
Supplier:: Elabscience
Host:: Rabbit
Reactivities:: Human, Mouse, Rat
Buffer:: Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Immunogen:: Recombinant fusion protein of human NLRP10
Uniprot:: Q86W26
Synonyms:: CLR11.1;NACHT, leucine rich repeat and PYD containing 10;NACHT, LRR and PYD domains-containing protein 10;NALP10;NOD8;nucleotide-binding oligomerization domain protein 8;nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 10;PAN5;PYNOD
Extra Details:: Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). The protein encoded by this gene belongs to the NALP protein family despite lacking the LRR region. This protein likely plays a regulatory role in the innate immune system. The protein belongs to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, caspase-1 and caspase-5. Other experiments indicate that this gene acts as a multifunctional negative regulator of inflammation and apoptosis.