E-AB-91147
CRTC1 Polyclonal Antibody
Size
£195.30
Was £217.00
- SKU:
- E-AB-91147
- Additional Names:
- CRTC1,MECT1,TORC-1,TORC1,WAMTP1
- Application:
- WB
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Recombinant fusion protein of human CRTC1
- Uniprot:
- Q6UUV9
- Synonyms:
- CREB-regulated transcription coactivator 1;Mam-2;MAML2;Mastermind-like protein 2;MECT1;mucoepidermoid carcinoma translocated protein 1;TORC-1;TORC1;transducer of regulated cAMP response element-binding protein (CREB) 1;Transducer of regulated cAMP response element-binding protein 1;WAMTP1
- Extra Details:
- Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. In the hippocampus, involved in late-phase long-term potentiation (L-LTP maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons (By similarity. In concert with SIK1, regulates the light-induced entrainment of the circadian clock. In response to light stimulus, coactivates the CREB-mediated transcription of PER1 which plays an important role in the photic entrainment of the circadian clock.
- Shipping Conditions:
- Blue Ice