E-AB-90992
CDK12 Polyclonal Antibody
Size
£211.50
Was £235.00
- SKU:
- E-AB-90992
- Additional Names:
- CDK12,CRK7,CRKR,CRKRS
- Application:
- IHC, WB
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Recombinant fusion protein of human CDK12
- Uniprot:
- Q9NYV4
- Synonyms:
- Cdc2-related kinase, arginine/serine-rich;CDC2-related protein kinase 7;cell division cycle 2-related protein kinase 7;cell division protein kinase 12;CRK7;CRKR;CRKRS;cyclin-dependent kinase 12
- Extra Details:
- Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD of the large subunit of RNA polymerase II (POLR2A, thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors.
- Shipping Conditions:
- Blue Ice