E-AB-90954
TYROBP Polyclonal Antibody
Size
£195.30
Was £217.00
- SKU:
- E-AB-90954
- Additional Names:
- DAP12,KARAP,PLOSL,TYROBP
- Application:
- WB
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- A synthetic peptide of human TYROBP
- Uniprot:
- O43914
- Synonyms:
- DAP12;DNAX adaptor protein 12;DNAX-activation protein 12;KAR-associated protein;KARAP;killer-activating receptor-associated protein;PLOSL;PLOSL1;polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy;TYRO protein tyrosine kinase binding protein;TYRO protein tyrosine kinase-binding protein
- Extra Details:
- This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene.
- Shipping Conditions:
- Blue Ice