E-AB-90904
RYBP Polyclonal Antibody
Size
£195.30
Was £217.00
- SKU:
- E-AB-90904
- Additional Names:
- AAP1,APAP-1,DEDAF,RYBP,YEAF1
- Application:
- WB
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- A synthetic peptide of human RYBP
- Uniprot:
- Q8N488
- Synonyms:
- AAP1;APAP-1;apoptin-associating protein 1;death effector domain-associated factor;DED-associated factor;DEDAF;RING1 and YY1-binding protein;ring1 interactor RYBP;YEAF1;YY1 and E4TF1 associated factor 1;YY1 and E4TF1-associated factor 1
- Extra Details:
- Component of a Polycomb group (PcG multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1-like complex acts via chromatin remodeling and modification of histones, it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Component of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females. May stimulate ubiquitination of histone H2A 'Lys-119' by recruiting the complex to target sites (By similarity. Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes. May also regulate the ubiquitin-mediated proteasomal degradation of other proteins like FANK1 to regulate apoptosis. May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1. May bind to DNA (By similarity. May play a role in the repression of tumor growth and metastasis in breast cancer by down-regulating SRRM3.
- Shipping Conditions:
- Blue Ice