E-AB-90796
TRMT112 Polyclonal Antibody
Size
£195.30
Was £217.00
- SKU:
- E-AB-90796
- Additional Names:
- HSPC152,HSPC170,TRM112,TRMT11-2,TRMT112,hTrm112
- Application:
- WB
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Recombinant fusion protein of human TRMT112
- Uniprot:
- Q9UI30
- Synonyms:
- HSPC152;HSPC170;hTrm112;multifunctional methyltransferase subunit TRM112-like protein;TRM112;TRM112-like protein;TRMT11-2;tRNA methyltransferase 11-2 homolog;tRNA methyltransferase 112 homolog;tRNA methyltransferase subunit 11-2
- Extra Details:
- Acts as an activator of both rRNA/tRNA and protein methyltransferases. Together with methyltransferase BUD23, methylates the N(7 position of a guanine in 18S rRNA. The heterodimer with HEMK2/N6AMT1 catalyzes N5-methylation of ETF1 on 'Gln-185', using S-adenosyl L-methionine as methyl donor. The heterodimer with HEMK2/N6AMT1 also monomethylates 'Lys-12' of histone H4 (H4K12me1. The heterodimer with ALKBH8 catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA species. Involved in the pre-rRNA processing steps leading to small-subunit rRNA production. Together with methyltransferase METTL5, specifically methylates the 6th position of adenine in position 1832 of 18S rRNA.
- Shipping Conditions:
- Blue Ice