E-AB-90595
Rubicon Polyclonal Antibody
Size
£195.30
Was £217.00
- SKU:
- E-AB-90595
- Additional Names:
- KIAA0226,RUBCN,RUBICON,SCAR15
- Application:
- WB
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Mouse
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Recombinant fusion protein of human Rubicon
- Uniprot:
- Q92622
- Synonyms:
- baron;beclin-1 associated RUN domain containing protein;KIAA0226;RUBICON;RUN and cysteine rich domain containing beclin 1 interacting protein;RUN domain and cysteine-rich domain containing, Beclin 1-interacting protein;run domain Beclin-1-interacting and cysteine-rich domain-containing protein;rundataxin;SCAR15
- Extra Details:
- The protein encoded by this gene is a negative regulator of autophagy and endocytic trafficking and controls endosome maturation. This protein contains two conserved domains, an N-terminal RUN domain and a C-terminal DUF4206 domain. The RUN domain is involved in Ras-like GTPase signaling, and the DUF4206 domain contains a diacylglycerol (DAG) binding-like motif. Mutation in this gene results in deletion of the DAG binding-like motif and causes a recessive ataxia. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
- Shipping Conditions:
- Blue Ice