E-AB-90482
LIFR Polyclonal Antibody
Size
£195.30
Was £217.00
- SKU:
- E-AB-90482
- Additional Names:
- CD118,LIF-R,LIFR,SJS2,STWS,SWS
- Application:
- WB
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Mouse
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Recombinant fusion protein of human LIFR
- Uniprot:
- P42702
- Synonyms:
- CD118;CD118 antigen;leukemia inhibitory factor receptor;leukemia inhibitory factor receptor alpha;LIF receptor alpha;LIF-R;SJS2;STWS;SWS
- Extra Details:
- This gene encodes a protein that belongs to the type I cytokine receptor family. This protein combines with a high-affinity converter subunit, gp130, to form a receptor complex that mediates the action of the leukemia inhibitory factor, a polyfunctional cytokine that is involved in cellular differentiation, proliferation and survival in the adult and the embryo. Mutations in this gene cause Schwartz-Jampel syndrome type 2, a disease belonging to the group of the bent-bone dysplasias. A translocation that involves the promoter of this gene, t(5,8)(p13,q12) with the pleiomorphic adenoma gene 1, is associated with salivary gland pleiomorphic adenoma, a common type of benign epithelial tumor of the salivary gland. Multiple splice variants encoding the same protein have been found for this gene.
- Shipping Conditions:
- Blue Ice